Giulio Romano, a student and collaborator of Raphael, is a significant figure of the Italian Renaissance, particularly recognized for his role in the transition to Mannerism. Romano, born Giulio Pippi, is famous for his works in the Palazzo del Te in Mantua and for introducing elements of surprise and dynamism in painting and architecture.

The work presented here, attributed to the circle of Giulio Romano, well illustrates the influence of Raphael while heralding Mannerist characteristics: a harmonious yet complex composition, figures in elegant poses, and a bold use of color and light. The Virgin Mary, dressed in her traditional red and blue colors, is depicted in a prayerful posture, while the naked Child Jesus interacts with Saint Anne. Saint Joseph, in the background, completes the Holy Family, adding narrative depth to the scene.

The execution of this painting shows great technical mastery: delicate draperies, gentle expressions, and luminous halos testify to a finesse characteristic of Raphael's school. The prestigious provenance of the work, having belonged to Palazzo Paicos in Berlin, adds to its historical and artistic interest.

This painting captures an intimate and sacred moment with remarkable sensitivity, illustrating both religious devotion and the artistic skill of the Renaissance. The attention to detail, the depth of composition, and the tenderness of interactions between the characters make it a representative work of the era and style of Giulio Romano and his workshop.